RETINAL ORGANOIDFrontier / Organoids
Human tissue, grown outside the body. What can it reveal about disease—and how close does it come to the real thing?
Explore the briefCoverage in development
Coverage in development
Vaccines & clinical trials
A closer look at mNEXSPIKE: a redesigned antigen, a lower mRNA dose and the trial behind its first US approval.
Explore the briefBiological datasets
Before an AI model learns biology, someone has to decide what to measure. The story starts with the cells, the experiments and the people missing from the dataset.
Explore the brief
Protein design
Design a new protein to bind a chosen target. Then make it, measure it, and find out what that encounter can do.
Explore the briefThe podcast
Amgen
Episode 02 / 1 hr 5 min
The search for EPO, the deals that built Amgen, and the costs of its success.
Listen to the episodeEli Lilly
Episode 01 / 1 hr 6 min
The Toronto discovery, the Indianapolis factory, and the problem of making enough insulin.
Listen to the episodeEssays / Research / Opinion
AI × biology
How a concept-bottleneck model uses bulk tumor RNA sequencing to estimate response to checkpoint inhibitors, and why retrospective results still need prospective validation.
Tools & experiments
From RAG to context engineering: notes from building a research companion.
Biotech & business
China is changing where medicines are discovered. Ivonescimab’s path from Akeso to Summit shows why the route to global approval is more complicated.
The New Alchemist / Volume one
Every era of medicine began with a new way to make it.
Archival photographs, scientific diagrams and company histories. Six parts, from the first medicine factories to protein design.
Inside the book
